Assay Detail
Binding
CHEMBL3757878
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Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
D1-like receptors distinguishing thieno-azecine regioisomers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.25 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201170 | — | — | 1 | 9.40 |
| CHEMBL441618 | — | — | 1 | 8.72 |
| CHEMBL201093 | — | — | 1 | 8.40 |
| CHEMBL201525 | — | — | 1 | 8.35 |
| CHEMBL3753266 | — | — | 1 | 7.40 |
| CHEMBL3752512 | — | — | 1 | 7.22 |
| CHEMBL3752882 | — | — | 1 | - |
| CHEMBL3753195 | — | — | 1 | - |
| CHEMBL3754576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201170 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL441618 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL201093 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL201525 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL3753266 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3752512 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3752882 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3753195 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3754576 | — | Ki | > | 1000.0 | nM | - |