Assay Detail
Binding
CHEMBL3758061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.94 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752685 | — | — | 1 | 9.09 |
| CHEMBL3752467 | — | — | 1 | 9.07 |
| CHEMBL3753405 | — | — | 1 | 8.59 |
| CHEMBL3752543 | — | — | 1 | 7.97 |
| CHEMBL3752969 | — | — | 1 | 7.82 |
| CHEMBL3753850 | — | — | 1 | 7.61 |
| CHEMBL3752119 | — | — | 1 | 7.49 |
| CHEMBL3752926 | — | — | 1 | 7.36 |
| CHEMBL3751941 | — | — | 1 | 7.33 |
| CHEMBL3754291 | — | — | 1 | 7.31 |
| CHEMBL3752356 | — | — | 1 | 7.20 |
| CHEMBL3751866 | — | — | 1 | 7.11 |
| CHEMBL3753360 | — | — | 1 | 6.93 |
| CHEMBL3754005 | — | — | 1 | 6.70 |
| CHEMBL3754672 | — | — | 1 | 6.70 |
| CHEMBL3752384 | — | — | 1 | 6.65 |
| CHEMBL3753957 | — | — | 1 | 6.58 |
| CHEMBL3753706 | — | — | 1 | 6.51 |
| CHEMBL3754480 | — | — | 1 | 6.49 |
| CHEMBL3754146 | — | — | 1 | 6.38 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.37 |
| CHEMBL3752451 | — | — | 1 | 6.37 |
| CHEMBL3752555 | — | — | 1 | 6.26 |
| CHEMBL3754739 | — | — | 1 | 6.00 |
| CHEMBL3754778 | — | — | 1 | 5.99 |
| CHEMBL3753508 | — | — | 1 | 5.77 |
| CHEMBL3754341 | — | — | 1 | 5.68 |
| CHEMBL3754694 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752685 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL3752467 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL3753405 | — | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL3752543 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3752969 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL3753850 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL3752119 | — | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL3752926 | — | IC50 | = | 44.2 | nM | 7.36 |
| CHEMBL3751941 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3754291 | — | IC50 | = | 48.6 | nM | 7.31 |
| CHEMBL3752356 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3751866 | — | IC50 | = | 76.9 | nM | 7.11 |
| CHEMBL3753360 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3754005 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL3754672 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3752384 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL3753957 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3753706 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL3754480 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL3754146 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL95 | TACRINE | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL3752451 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL3752555 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL3754739 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL3754778 | — | IC50 | = | 1036.0 | nM | 5.99 |
| CHEMBL3753508 | — | IC50 | = | 1685.0 | nM | 5.77 |
| CHEMBL3754341 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3754694 | — | IC50 | = | 7495.0 | nM | 5.12 |