Assay Detail
Binding
CHEMBL3760248
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Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 4.91 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.70 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 5.51 |
| CHEMBL1957177 | — | — | 1 | 5.14 |
| CHEMBL1957182 | — | — | 1 | 5.12 |
| CHEMBL1957176 | — | — | 1 | 5.12 |
| CHEMBL1955879 | — | — | 1 | 5.10 |
| CHEMBL1957179 | — | — | 1 | 5.09 |
| CHEMBL1957178 | — | — | 1 | 5.08 |
| CHEMBL1957181 | — | — | 1 | 5.07 |
| CHEMBL1957175 | — | — | 1 | 5.06 |
| CHEMBL1957183 | — | — | 1 | 5.03 |
| CHEMBL1957172 | — | — | 1 | 4.52 |
| CHEMBL1957180 | — | — | 1 | 4.37 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 4.23 |
| CHEMBL432745 | 7-ALLYLOXYCOUMARIN | — | 1 | 4.14 |
| CHEMBL308819 | — | — | 1 | 4.14 |
| CHEMBL301141 | 4-HYDROXYCOUMARINS | — | 1 | 4.02 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | — | 1 | - |
| CHEMBL3759932 | — | — | 1 | - |
| CHEMBL3760092 | — | — | 1 | - |
| CHEMBL3758522 | — | — | 1 | - |
| CHEMBL3623663 | — | — | 1 | - |
| CHEMBL3758827 | — | — | 1 | - |
| CHEMBL3121782 | — | — | 1 | - |
| CHEMBL3760055 | — | — | 1 | - |
| CHEMBL3759409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL6466 | COUMARIN | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL1957177 | — | Ki | = | 7170.0 | nM | 5.14 |
| CHEMBL1957182 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL1957176 | — | Ki | = | 7570.0 | nM | 5.12 |
| CHEMBL1955879 | — | Ki | = | 8020.0 | nM | 5.10 |
| CHEMBL1957179 | — | Ki | = | 8180.0 | nM | 5.09 |
| CHEMBL1957178 | — | Ki | = | 8320.0 | nM | 5.08 |
| CHEMBL1957181 | — | Ki | = | 8510.0 | nM | 5.07 |
| CHEMBL1957175 | — | Ki | = | 8780.0 | nM | 5.06 |
| CHEMBL1957183 | — | Ki | = | 9240.0 | nM | 5.03 |
| CHEMBL1957172 | — | Ki | = | 30300.0 | nM | 4.52 |
| CHEMBL1957180 | — | Ki | = | 43200.0 | nM | 4.37 |
| CHEMBL51628 | UMBELLIFERONE | Ki | = | 58400.0 | nM | 4.23 |
| CHEMBL432745 | 7-ALLYLOXYCOUMARIN | Ki | = | 72900.0 | nM | 4.14 |
| CHEMBL308819 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL301141 | 4-HYDROXYCOUMARINS | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | Ki | > | 100000.0 | nM | - |
| CHEMBL3759932 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3760092 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3758522 | — | Ki | = | 950000.0 | nM | - |
| CHEMBL3623663 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL3758827 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL3121782 | — | Ki | = | 124000.0 | nM | - |
| CHEMBL3760055 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL3759409 | — | Ki | > | 100000.0 | nM | - |