Assay Detail
Functional
CHEMBL3761232
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Cytotoxic activity against human HCT116 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.72 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3758801 | — | — | 1 | 5.22 |
| CHEMBL3760052 | — | — | 1 | 4.95 |
| CHEMBL3759248 | — | — | 1 | 4.94 |
| CHEMBL3759783 | — | — | 1 | 4.92 |
| CHEMBL3759818 | — | — | 1 | 4.91 |
| CHEMBL3759902 | — | — | 1 | 4.88 |
| CHEMBL3759598 | — | — | 1 | 4.69 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.61 |
| CHEMBL3759664 | — | — | 1 | 4.59 |
| CHEMBL12850 | DEHYDROABIETIC ACID | — | 1 | 4.52 |
| CHEMBL3758708 | — | — | 1 | 4.47 |
| CHEMBL3759966 | — | — | 1 | 4.35 |
| CHEMBL3759729 | — | — | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3758801 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL3760052 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL3759248 | — | IC50 | = | 11440.0 | nM | 4.94 |
| CHEMBL3759783 | — | IC50 | = | 11940.0 | nM | 4.92 |
| CHEMBL3759818 | — | IC50 | = | 12220.0 | nM | 4.91 |
| CHEMBL3759902 | — | IC50 | = | 13110.0 | nM | 4.88 |
| CHEMBL3759598 | — | IC50 | = | 20210.0 | nM | 4.69 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 24580.0 | nM | 4.61 |
| CHEMBL3759664 | — | IC50 | = | 25490.0 | nM | 4.59 |
| CHEMBL12850 | DEHYDROABIETIC ACID | IC50 | = | 30250.0 | nM | 4.52 |
| CHEMBL3758708 | — | IC50 | = | 34070.0 | nM | 4.47 |
| CHEMBL3759966 | — | IC50 | = | 44650.0 | nM | 4.35 |
| CHEMBL3759729 | — | IC50 | = | 56030.0 | nM | 4.25 |