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Assay Detail

CHEMBL3761316

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ADMET
Cytotoxicity against CHO cells by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Autocuration

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum.
Joubert J, Kapp E, Taylor D, Smith PJ, Malan SF.
Bioorg Med Chem Lett (2016) 26 : 1151 -1155
PubMed 26832222 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.18 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50588 EMETINE 4.0 1 7.21
CHEMBL1830325 1 5.13
CHEMBL1830323 1 5.10
CHEMBL1830320 1 5.09
CHEMBL76 CHLOROQUINE 4.0 1 4.45
CHEMBL1189234 1 4.07
CHEMBL391409 1 -
CHEMBL391732 1 -
CHEMBL3758459 1 -
CHEMBL3759841 1 -
CHEMBL3758822 1 -
CHEMBL2324177 1 -
CHEMBL2324188 1 -
CHEMBL2324192 1 -
CHEMBL1428 NIMODIPINE 4.0 1 -
CHEMBL6966 VERAPAMIL 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50588 EMETINE IC50 = 61.0 nM 7.21
CHEMBL1830325 IC50 = 7400.0 nM 5.13
CHEMBL1830323 IC50 = 8010.0 nM 5.10
CHEMBL1830320 IC50 = 8200.0 nM 5.09
CHEMBL76 CHLOROQUINE IC50 = 35800.0 nM 4.45
CHEMBL1189234 IC50 = 84800.0 nM 4.07
CHEMBL391409 IC50 > 10000.0 nM -
CHEMBL391732 IC50 > 322000.0 nM -
CHEMBL3758459 IC50 = 119000.0 nM -
CHEMBL3759841 IC50 > 254000.0 nM -
CHEMBL3758822 IC50 > 265000.0 nM -
CHEMBL2324177 IC50 > 414000.0 nM -
CHEMBL2324188 IC50 > 349000.0 nM -
CHEMBL2324192 IC50 > 368000.0 nM -
CHEMBL1428 NIMODIPINE IC50 - -
CHEMBL6966 VERAPAMIL IC50 - -