Assay Detail
Binding
CHEMBL3761494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR T790M/L858R mutant autophosphorylation in human H1975 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H1975 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.06 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3758739 | — | — | 1 | 6.43 |
| CHEMBL3758502 | — | — | 1 | 6.22 |
| CHEMBL3759096 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3758739 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3758502 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3759096 | — | IC50 | = | 3000.0 | nM | 5.52 |