Assay Detail
Binding
CHEMBL3761623
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Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.14 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3758188 | — | — | 1 | 7.75 |
| CHEMBL2104196 | BENZYLSULFAMIDE | 2.0 | 1 | 7.70 |
| CHEMBL3758586 | — | — | 1 | 7.68 |
| CHEMBL3759945 | — | — | 1 | 7.67 |
| CHEMBL1579806 | — | — | 1 | 7.66 |
| CHEMBL3758537 | — | — | 1 | 7.61 |
| CHEMBL248691 | — | — | 1 | 7.51 |
| CHEMBL3759307 | — | — | 1 | 7.42 |
| CHEMBL3760099 | — | — | 1 | 7.37 |
| CHEMBL3759587 | — | — | 1 | 7.37 |
| CHEMBL3758614 | — | — | 1 | 7.31 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL270671 | — | — | 1 | 6.38 |
| CHEMBL3760079 | — | — | 1 | 6.37 |
| CHEMBL3758702 | — | — | 1 | 6.36 |
| CHEMBL3758993 | — | — | 1 | 6.34 |
| CHEMBL3758347 | — | — | 1 | 6.33 |
| CHEMBL3758730 | — | — | 1 | - |
| CHEMBL3759717 | — | — | 1 | - |
| CHEMBL429915 | — | — | 1 | - |
| CHEMBL271911 | — | — | 1 | - |
| CHEMBL408619 | — | — | 1 | - |
| CHEMBL3758997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3758188 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL2104196 | BENZYLSULFAMIDE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3758586 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL3759945 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL1579806 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL3758537 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL248691 | — | Ki | = | 30.7 | nM | 7.51 |
| CHEMBL3759307 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL3760099 | — | Ki | = | 42.5 | nM | 7.37 |
| CHEMBL3759587 | — | Ki | = | 42.3 | nM | 7.37 |
| CHEMBL3758614 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL270671 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL3760079 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL3758702 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL3758993 | — | Ki | = | 458.0 | nM | 6.34 |
| CHEMBL3758347 | — | Ki | = | 463.0 | nM | 6.33 |
| CHEMBL3758730 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3759717 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL429915 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL271911 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL408619 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3758997 | — | Ki | > | 50000.0 | nM | - |