Assay Detail
Binding
CHEMBL3762038
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Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISA
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.95 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.85 |
| CHEMBL3758464 | — | — | 1 | 8.44 |
| CHEMBL3759495 | — | — | 1 | 8.37 |
| CHEMBL3758452 | — | — | 1 | 8.37 |
| CHEMBL3759100 | — | — | 1 | 8.25 |
| CHEMBL3758564 | — | — | 1 | 8.14 |
| CHEMBL3759079 | — | — | 1 | 8.12 |
| CHEMBL3759336 | — | — | 1 | 8.09 |
| CHEMBL3758926 | — | — | 1 | 7.98 |
| CHEMBL3760077 | — | — | 1 | 7.91 |
| CHEMBL3759611 | — | — | 1 | 7.87 |
| CHEMBL3758865 | — | — | 1 | 7.80 |
| CHEMBL3758752 | — | — | 1 | 7.80 |
| CHEMBL3758905 | — | — | 1 | 7.73 |
| CHEMBL3758780 | — | — | 1 | 7.70 |
| CHEMBL3759319 | — | — | 1 | 7.67 |
| CHEMBL3758647 | — | — | 1 | 7.55 |
| CHEMBL3759229 | — | — | 1 | 7.27 |
| CHEMBL3759320 | — | — | 1 | 7.09 |
| CHEMBL3758597 | — | — | 1 | - |
| CHEMBL3758362 | — | — | 1 | - |
| CHEMBL3758256 | — | — | 1 | - |
| CHEMBL3758539 | — | — | 1 | - |
| CHEMBL3758418 | — | — | 1 | - |
| CHEMBL3758187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3758464 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3759495 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3758452 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3759100 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3758564 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3759079 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3759336 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3758926 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL3760077 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL3759611 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL3758865 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL3758752 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL3758905 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL3758780 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL3759319 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL3758647 | — | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL3759229 | — | IC50 | = | 53.2 | nM | 7.27 |
| CHEMBL3759320 | — | IC50 | = | 82.1 | nM | 7.09 |
| CHEMBL3758597 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3758362 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3758256 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3758539 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3758418 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3758187 | — | IC50 | > | 100.0 | nM | - |