Assay Detail
Functional
CHEMBL3762039
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Antiproliferative activity against human EBC1 cells after 72 hrs by SRB assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EBC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.23 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.72 |
| CHEMBL3759079 | — | — | 1 | 7.51 |
| CHEMBL3758464 | — | — | 1 | 7.50 |
| CHEMBL3759611 | — | — | 1 | 7.31 |
| CHEMBL3759495 | — | — | 1 | 7.19 |
| CHEMBL3758452 | — | — | 1 | 7.19 |
| CHEMBL3758564 | — | — | 1 | 7.13 |
| CHEMBL3759336 | — | — | 1 | 7.02 |
| CHEMBL3758752 | — | — | 1 | 7.00 |
| CHEMBL3758865 | — | — | 1 | 6.99 |
| CHEMBL3759100 | — | — | 1 | 6.97 |
| CHEMBL3758187 | — | — | 1 | - |
| CHEMBL3758418 | — | — | 1 | - |
| CHEMBL3759320 | — | — | 1 | - |
| CHEMBL3758539 | — | — | 1 | - |
| CHEMBL3759319 | — | — | 1 | - |
| CHEMBL3758905 | — | — | 1 | - |
| CHEMBL3758256 | — | — | 1 | - |
| CHEMBL3758362 | — | — | 1 | - |
| CHEMBL3760077 | — | — | 1 | - |
| CHEMBL3758780 | — | — | 1 | - |
| CHEMBL3758647 | — | — | 1 | - |
| CHEMBL3758926 | — | — | 1 | - |
| CHEMBL3759229 | — | — | 1 | - |
| CHEMBL3758597 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3759079 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL3758464 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL3759611 | — | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL3759495 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3758452 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3758564 | — | IC50 | = | 73.4 | nM | 7.13 |
| CHEMBL3759336 | — | IC50 | = | 94.6 | nM | 7.02 |
| CHEMBL3758752 | — | IC50 | = | 99.8 | nM | 7.00 |
| CHEMBL3758865 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3759100 | — | IC50 | = | 108.1 | nM | 6.97 |
| CHEMBL3758187 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758418 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3759320 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758539 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3759319 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758905 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758256 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758362 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3760077 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758780 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758647 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758926 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3759229 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL3758597 | — | IC50 | > | 200.0 | nM | - |