Assay Detail
Binding
CHEMBL3762072
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Displacement of [3H]-prazosin from human alpha1 adrenoceptor expressed in HEK293 cells after 1 hr
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.21 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3759617 | — | — | 1 | 6.60 |
| CHEMBL3759205 | — | — | 1 | 6.47 |
| CHEMBL3759819 | — | — | 1 | 6.13 |
| CHEMBL3740054 | — | — | 1 | 6.01 |
| CHEMBL3758591 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3759617 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3759205 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL3759819 | — | Ki | = | 742.0 | nM | 6.13 |
| CHEMBL3740054 | — | Ki | = | 979.0 | nM | 6.01 |
| CHEMBL3758591 | — | Ki | = | 1525.0 | nM | 5.82 |