Assay Detail
Binding
CHEMBL3762136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.94 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 10.00 |
| CHEMBL3758502 | — | — | 1 | 9.22 |
| CHEMBL3759096 | — | — | 1 | 8.96 |
| CHEMBL3758602 | — | — | 1 | 8.82 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.46 |
| CHEMBL3758739 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3758502 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL3759096 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3758602 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3353410 | OSIMERTINIB | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL3758739 | — | Ki | = | 6.5 | nM | 8.19 |