Assay Detail
Binding
CHEMBL3762597
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Displacement of [3H]DAMGO from MOR in Wistar rat brain homogenates by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.78 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3759167 | — | — | 1 | 9.60 |
| CHEMBL1927270 | — | — | 1 | 9.46 |
| CHEMBL3759179 | — | — | 1 | 9.36 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 9.31 |
| CHEMBL3759981 | — | — | 1 | 7.77 |
| CHEMBL3758969 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3759167 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL1927270 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL3759179 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL3759981 | — | Ki | = | 16.82 | nM | 7.77 |
| CHEMBL3758969 | — | Ki | = | 69.18 | nM | 7.16 |