Assay Detail
Binding
CHEMBL3762646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nor-BNI from KOR in Dunkin Hartley guinea pig brain homogenates by liquid scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.53 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3759179 | — | — | 1 | 8.99 |
| CHEMBL1927270 | — | — | 1 | 8.95 |
| CHEMBL3759167 | — | — | 1 | 8.75 |
| CHEMBL3758969 | — | — | 1 | 7.25 |
| CHEMBL3759981 | — | — | 1 | 6.12 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3759179 | — | Ki | = | 1.02 | nM | 8.99 |
| CHEMBL1927270 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL3759167 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL3758969 | — | Ki | = | 56.62 | nM | 7.25 |
| CHEMBL3759981 | — | Ki | = | 750.7 | nM | 6.12 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 7827.67 | nM | 5.11 |