Assay Detail
Functional
CHEMBL3762917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.63 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 9.74 |
| CHEMBL3759802 | — | — | 1 | 9.15 |
| CHEMBL3758717 | — | — | 1 | 9.01 |
| CHEMBL3758679 | — | — | 1 | 9.01 |
| CHEMBL3759084 | — | — | 1 | 8.96 |
| CHEMBL3758225 | — | — | 1 | 8.85 |
| CHEMBL3759606 | — | — | 1 | 8.49 |
| CHEMBL3759160 | — | — | 1 | 8.47 |
| CHEMBL3759859 | — | — | 1 | 8.24 |
| CHEMBL3760044 | — | — | 1 | 8.21 |
| CHEMBL3759816 | — | — | 1 | 8.06 |
| CHEMBL3759054 | — | — | 1 | 8.06 |
| CHEMBL3759080 | — | — | 1 | 8.00 |
| CHEMBL3758720 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10878 | AGOMELATINE | EC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3759802 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3758717 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3758679 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3759084 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3758225 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3759606 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3759160 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3759859 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3760044 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3759816 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3759054 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3759080 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3758720 | — | EC50 | > | 10000.0 | nM | - |