Assay Detail
Functional
CHEMBL3766299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at dog beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-3 adrenergic receptor (CHEMBL4400) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.58 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107826 | VIBEGRON | 4.0 | 1 | 7.96 |
| CHEMBL111201 | — | — | 1 | 7.60 |
| CHEMBL3765335 | — | — | 1 | 7.41 |
| CHEMBL3764088 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107826 | VIBEGRON | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL111201 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3765335 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3764088 | — | EC50 | = | 47.0 | nM | 7.33 |