Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3766324

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human KBVIN cells after 3 days by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KBVIN
Confidence 1 — Organism
Curated By Autocuration

Publication

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
Tan CJ, Zhao Y, Goto M, Hsieh KY, Yang XM, Morris-Natschke SL, Liu LN, Zhao BY, Lee KH.
Bioorg Med Chem Lett (2016) 26 : 1495 -1497
PubMed 26865176 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.80 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 5.58
CHEMBL3765322 1 4.67
CHEMBL3765504 1 4.14
CHEMBL3765047 1 -
CHEMBL3765803 1 -
CHEMBL3763538 1 -
CHEMBL3764263 1 -
CHEMBL3763471 1 -
CHEMBL3764665 1 -
CHEMBL204747 1 -
CHEMBL382625 1 -
CHEMBL3763416 1 -
CHEMBL377725 SOPHOCARPINE 1 -
CHEMBL3765820 1 -
CHEMBL3590540 1 -
CHEMBL204860 MATRINE 1 -
CHEMBL3764664 1 -
CHEMBL1824581 SOPHORIDINE 1 -
CHEMBL3763553 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 2600.0 nM 5.58
CHEMBL3765322 IC50 = 21600.0 nM 4.67
CHEMBL3765504 IC50 = 72000.0 nM 4.14
CHEMBL3765047 IC50 > 40000.0 nM -
CHEMBL3765803 IC50 > 40000.0 nM -
CHEMBL3763538 IC50 > 40000.0 nM -
CHEMBL3764263 IC50 > 80000.0 nM -
CHEMBL3763471 IC50 > 80000.0 nM -
CHEMBL3764665 IC50 > 40000.0 nM -
CHEMBL204747 IC50 > 40000.0 nM -
CHEMBL382625 IC50 > 40000.0 nM -
CHEMBL3763416 IC50 > 40000.0 nM -
CHEMBL377725 SOPHOCARPINE IC50 > 40000.0 nM -
CHEMBL3765820 IC50 > 40000.0 nM -
CHEMBL3590540 IC50 > 40000.0 nM -
CHEMBL204860 MATRINE IC50 > 40000.0 nM -
CHEMBL3764664 IC50 > 40000.0 nM -
CHEMBL1824581 SOPHORIDINE IC50 > 80000.0 nM -
CHEMBL3763553 IC50 > 40000.0 nM -