Assay Detail
Binding
CHEMBL3766401
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Inhibition of human 12/15-LOX expressed in HEK293 cells after 30 mins by microplate reader analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent and selective inhibitor targeting human and murine 12/15-LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.09 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180917 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180917 | — | IC50 | = | 810.0 | nM | 6.09 |