Assay Detail
Functional
CHEMBL3766648
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Antiproliferative activity against human PC3 cells assessed as inhibition of cell viability after 3 days by WST-1 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 1,7-diheteroarylhepta-1,4,6-trien-3-ones as curcumin-based anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.70 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764186 | — | — | 1 | 6.16 |
| CHEMBL3765782 | — | — | 1 | 5.99 |
| CHEMBL3763602 | — | — | 1 | 5.97 |
| CHEMBL3764322 | — | — | 1 | 5.81 |
| CHEMBL3764225 | — | — | 1 | 5.80 |
| CHEMBL3763797 | — | — | 1 | 5.79 |
| CHEMBL3764375 | — | — | 1 | 5.73 |
| CHEMBL3763425 | — | — | 1 | 5.64 |
| CHEMBL3765753 | — | — | 1 | 5.59 |
| CHEMBL3765359 | — | — | 1 | 5.59 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764186 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3765782 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3763602 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3764322 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3764225 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL3763797 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL3764375 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL3763425 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL3765753 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3765359 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL140 | CURCUMIN | IC50 | = | 25430.0 | nM | 4.59 |