Assay Detail
Binding
CHEMBL3766659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 in human Jurkat cells assessed as reduction in IL-23-induced luciferase gene expression after 24 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.55 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763991 | — | — | 1 | 7.32 |
| CHEMBL3763252 | — | — | 1 | 7.27 |
| CHEMBL3764277 | — | — | 1 | 6.96 |
| CHEMBL3764030 | — | — | 1 | 6.82 |
| CHEMBL3765822 | — | — | 1 | 6.72 |
| CHEMBL3763213 | — | — | 1 | 6.70 |
| CHEMBL3765517 | — | — | 1 | 6.64 |
| CHEMBL3764637 | — | — | 1 | 6.51 |
| CHEMBL3764383 | — | — | 1 | 6.36 |
| CHEMBL3764167 | — | — | 1 | 6.19 |
| CHEMBL3763697 | — | — | 1 | 5.96 |
| CHEMBL3763184 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763991 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3763252 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3764277 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3764030 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3765822 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3763213 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3765517 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3764637 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3764383 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3764167 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3763697 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3763184 | — | IC50 | = | 6900.0 | nM | 5.16 |