Assay Detail
Binding
CHEMBL3766852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit muscle glycogen phosphorylase b
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, muscle form (CHEMBL4696) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.83 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763876 | — | — | 1 | 5.81 |
| CHEMBL3764775 | — | — | 1 | 5.25 |
| CHEMBL3764271 | — | — | 1 | 5.21 |
| CHEMBL3765663 | — | — | 1 | 5.00 |
| CHEMBL3763976 | — | — | 1 | 4.88 |
| CHEMBL3763651 | — | — | 1 | 4.60 |
| CHEMBL3763810 | — | — | 1 | 4.56 |
| CHEMBL3764195 | — | — | 1 | 4.09 |
| CHEMBL3763929 | — | — | 1 | 4.09 |
| CHEMBL3764911 | — | — | 1 | - |
| CHEMBL3764090 | — | — | 1 | - |
| CHEMBL3764673 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763876 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3764775 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3764271 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3765663 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3763976 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3763651 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3763810 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL3764195 | — | IC50 | = | 80500.0 | nM | 4.09 |
| CHEMBL3763929 | — | IC50 | = | 81300.0 | nM | 4.09 |
| CHEMBL3764911 | — | IC50 | = | 324700.0 | nM | - |
| CHEMBL3764090 | — | IC50 | = | 800000.0 | nM | - |
| CHEMBL3764673 | — | IC50 | = | 280000.0 | nM | - |