Assay Detail
Binding
CHEMBL3766855
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Inhibition of glycogen phosphorylase in human hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxidase method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Hepatocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.98 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765349 | — | — | 1 | 5.60 |
| CHEMBL594021 | — | — | 1 | 4.70 |
| CHEMBL3763876 | — | — | 1 | 4.65 |
| CHEMBL3764775 | — | — | 1 | - |
| CHEMBL3764911 | — | — | 1 | - |
| CHEMBL3764195 | — | — | 1 | - |
| CHEMBL3763929 | — | — | 1 | - |
| CHEMBL3763976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765349 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL594021 | — | IC50 | = | 19950.0 | nM | 4.70 |
| CHEMBL3763876 | — | IC50 | = | 22160.0 | nM | 4.65 |
| CHEMBL3764775 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763976 | — | IC50 | > | 100000.0 | nM | - |