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Target Snapshot

CHEMBL2568 Target Snapshot

Glycogen phosphorylase, liver form · SINGLE PROTEIN · Homo sapiens

817Compounds
58Assays
0Approved Drugs
1,025.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P06737. Use UniProt P06737 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P06737 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glycogen phosphorylase, liver form as ChEMBL target CHEMBL2568, mapped to UniProt P06737. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glycogen phosphorylase, liver form
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2568
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P06737
Glycogen phosphorylase, liver form
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glycogen phosphorylase, liver form is the right protein anchor across sources, using UniProt P06737 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlycogen phosphorylase, liver form
UniProt AccessionP06737
Component TypeProtein
Sequence Length847 aa

Glycogen phosphorylase, liver form

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glycogen phosphorylase, liver form, mapped to UniProt P06737. Sequence length is 847 aa.

Mapped IDP06737
Review nameGlycogen phosphorylase, liver form
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50738.0
KI43.0
KD244.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL133911 9.0 IC50 1.0 Preclinical
CHEMBL134802 9.0 IC50 1.0 Preclinical
CHEMBL115651 8.7 IC50 2.0 Preclinical
CHEMBL133832 8.7 IC50 2.0 Preclinical
CHEMBL394526 8.7 IC50 2.0 Preclinical
CHEMBL440528 8.7 IC50 2.0 Preclinical
CHEMBL3752910 8.62 Kd 2.394 Preclinical
CHEMBL132191 8.52 IC50 3.0 Preclinical
CHEMBL458655 8.52 IC50 3.0 Preclinical
CHEMBL471266 8.52 IC50 3.0 Preclinical
Distribution

pChEMBL Value Distribution

52
5.0
114
5.5
130
6.0
161
6.5
109
7.0
61
7.5
27
8.0
8
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

58
Total Assays
620
Tested Compounds
1
Assay Types
Binding — 58 assays, 620 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 35 362 6.5
cell-based format 10 87 6.0
single protein format 9 166 6.5
tissue-based format 3 4 6.5
subcellular format 1 1 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine