Compound Detail
CHEMBL394526
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Basic Information
| ChEMBL ID | CHEMBL394526 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OZBWIUILLXYRCQ-RWANSRKNSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
454.3
MW (Da)
2.58
ALogP
5
HBA
4
HBD
105.7
PSA (Ų)
0.48
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen phosphorylase, liver form CHEMBL2568 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Hepatocyte CHEMBL613362 | IC50 | 6.58 | 6.58 | 260.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, liver form | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human hepatic recombinant glycogen phosphorylase by multienzyme co... | 17095214 |
| Hepatocyte | IC50 | = | 260.0 | nM | 6.58 | Inhibition of glucose output in glucagon challenged primary rat hepatocytes | 17095214 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17095214 | 10.1016/j.bmcl.2006.10.037 | Glycogen phosphorylase, liver form | 1 |
| 17095214 | 10.1016/j.bmcl.2006.10.037 | Hepatocyte | 1 |
| 17095214 | 10.1016/j.bmcl.2006.10.037 | Plasma | 1 |
| 17095214 | 10.1016/j.bmcl.2006.10.037 | No relevant target | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine