Assay Detail
Binding
CHEMBL3766865
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Displacement of [3H]DAMGO from rat cortical MOR by liquid scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.83 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 9.15 |
| CHEMBL3765059 | — | — | 1 | 9.00 |
| CHEMBL3763920 | — | — | 1 | 8.71 |
| CHEMBL3764556 | — | — | 1 | 8.70 |
| CHEMBL3764157 | — | — | 1 | 8.04 |
| CHEMBL3763985 | — | — | 1 | 8.04 |
| CHEMBL3763495 | — | — | 1 | 7.85 |
| CHEMBL3765741 | — | — | 1 | 7.76 |
| CHEMBL3763905 | — | — | 1 | 6.94 |
| CHEMBL3764234 | — | — | 1 | 6.00 |
| CHEMBL3763452 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3765059 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL3763920 | — | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL3764556 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL3764157 | — | Ki | = | 9.04 | nM | 8.04 |
| CHEMBL3763985 | — | Ki | = | 9.21 | nM | 8.04 |
| CHEMBL3763495 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3765741 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL3763905 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL3764234 | — | Ki | = | 991.0 | nM | 6.00 |
| CHEMBL3763452 | — | Ki | = | 1129.0 | nM | 5.95 |