Assay Detail
Binding
CHEMBL3766866
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Displacement of [3H]U69,593 from guinea pig KOR after 2 hrs by liquid scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.23 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763495 | — | — | 1 | 5.49 |
| CHEMBL3765059 | — | — | 1 | 5.35 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 5.29 |
| CHEMBL3763920 | — | — | 1 | 5.27 |
| CHEMBL3764556 | — | — | 1 | 5.09 |
| CHEMBL3764157 | — | — | 1 | 5.07 |
| CHEMBL3765741 | — | — | 1 | 5.07 |
| CHEMBL3763985 | — | — | 1 | - |
| CHEMBL3763452 | — | — | 1 | - |
| CHEMBL3764234 | — | — | 1 | - |
| CHEMBL3763905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763495 | — | Ki | = | 3231.0 | nM | 5.49 |
| CHEMBL3765059 | — | Ki | = | 4450.0 | nM | 5.35 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 5069.0 | nM | 5.29 |
| CHEMBL3763920 | — | Ki | = | 5330.0 | nM | 5.27 |
| CHEMBL3764556 | — | Ki | = | 8160.0 | nM | 5.09 |
| CHEMBL3764157 | — | Ki | = | 8430.0 | nM | 5.07 |
| CHEMBL3765741 | — | Ki | = | 8530.0 | nM | 5.07 |
| CHEMBL3763985 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763452 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764234 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763905 | — | Ki | > | 10000.0 | nM | - |