Assay Detail
Binding
CHEMBL3767080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin) incubated for 60 mins by kinase-glo luminescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.33 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765105 | — | — | 1 | 5.55 |
| CHEMBL3765574 | — | — | 1 | 5.52 |
| CHEMBL3764119 | — | — | 1 | 5.48 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.40 |
| CHEMBL3763205 | — | — | 1 | 5.00 |
| CHEMBL3763878 | — | — | 1 | 5.00 |
| CHEMBL3763707 | — | — | 1 | - |
| CHEMBL3763897 | — | — | 1 | - |
| CHEMBL3764800 | — | — | 1 | - |
| CHEMBL3763440 | — | — | 1 | - |
| CHEMBL3763957 | — | — | 1 | - |
| CHEMBL3765350 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765105 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3765574 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3764119 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL98350 | LY-294002 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3763205 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3763878 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3763707 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3763897 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3764800 | — | IC50 | - | — | - | |
| CHEMBL3763440 | — | IC50 | - | — | - | |
| CHEMBL3763957 | — | IC50 | - | — | - | |
| CHEMBL3765350 | — | IC50 | - | — | - |