Assay Detail
Binding
CHEMBL3767151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKKbeta in primary type-2 collagen immunized mouse splenocytes assessed as inhibition of TNFalpha production at 10 uM after 72 hrs by ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL6012) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Identification and characterization of potent, selective and metabolically stable IKKβ inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.36 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765499 | — | — | 1 | 6.30 |
| CHEMBL3765155 | — | — | 1 | 5.70 |
| CHEMBL2070413 | — | — | 1 | 5.70 |
| CHEMBL3764369 | — | — | 1 | 5.52 |
| CHEMBL3764354 | — | — | 1 | 5.40 |
| CHEMBL3765189 | — | — | 1 | 5.40 |
| CHEMBL3764955 | — | — | 1 | 5.40 |
| CHEMBL3763698 | — | — | 1 | 5.30 |
| CHEMBL3764998 | — | — | 1 | 5.22 |
| CHEMBL3763572 | — | — | 1 | 5.22 |
| CHEMBL3765759 | — | — | 1 | 5.10 |
| CHEMBL3764641 | — | — | 1 | 4.70 |
| CHEMBL3763983 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765499 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3765155 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2070413 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3764369 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3764354 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3765189 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3764955 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3763698 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3764998 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3763572 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3765759 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3764641 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3763983 | — | IC50 | = | 20000.0 | nM | 4.70 |