Assay Detail
Functional
CHEMBL3767401
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Antiviral activity against HCV genotype 2a by replicon assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 10.10 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764806 | — | — | 1 | 11.00 |
| CHEMBL3763385 | — | — | 1 | 10.70 |
| CHEMBL3764594 | — | — | 1 | 10.70 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 10.40 |
| CHEMBL3764511 | — | — | 1 | 10.40 |
| CHEMBL3765278 | — | — | 1 | 9.60 |
| CHEMBL3765311 | — | — | 1 | 9.40 |
| CHEMBL3763866 | — | — | 1 | 8.62 |
| CHEMBL3763554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764806 | — | EC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3763385 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3764594 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3764511 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3765278 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3765311 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3763866 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3763554 | — | EC50 | = | 0.004 | nM | - |