Compound Detail
CHEMBL3763554
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc4c(ccc5nc([C@@H]6C[Si](C)(C)CN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c54)c3)cc2)[nH]1)C(C)C
Basic Information
| ChEMBL ID | CHEMBL3763554 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RLLQAFALJVVRHS-ZYADHFCISA-N |
1
Targets
5
Activities
1
Assay Types
2
PK Parameters
2
Publications
0
Known Names
Molecular Properties
807.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 9.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis C virus CHEMBL379 | EC50 | 9.59 | 8.525 | 0.3 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 3.2 | uM.hr/ml | Rattus norvegicus |
| T1/2 | 6.6 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis C virus | EC50 | = | 0.26 | nM | 9.59 | Antiviral activity against HCV genotype 3a by replicon assay | 26850003 |
| Hepatitis C virus | EC50 | = | 35.0 | nM | 7.46 | Antiviral activity against HCV genotype 1a expressing NS5A Y93H mutant by replic... | 26850003 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26850003 | 10.1016/j.bmcl.2016.01.050 | Hepatitis C virus | 5 |
| 26850003 | 10.1016/j.bmcl.2016.01.050 | Rattus norvegicus | 2 |
Data from ChEMBL 36 via Core Engine