Assay Detail
Functional
CHEMBL3767404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1a expressing NS5A Y93H mutant by replicon assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 6.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764984 | — | — | 1 | 8.00 |
| CHEMBL3765311 | — | — | 1 | 7.62 |
| CHEMBL3764454 | — | — | 1 | 7.57 |
| CHEMBL3765413 | — | — | 1 | 7.52 |
| CHEMBL3763554 | — | — | 1 | 7.46 |
| CHEMBL3763933 | — | — | 1 | 7.36 |
| CHEMBL3765513 | — | — | 1 | 7.34 |
| CHEMBL3763799 | — | — | 1 | 7.19 |
| CHEMBL3765459 | — | — | 1 | 7.06 |
| CHEMBL3764176 | — | — | 1 | 7.05 |
| CHEMBL3764511 | — | — | 1 | 7.04 |
| CHEMBL3764594 | — | — | 1 | 7.02 |
| CHEMBL3763385 | — | — | 1 | 6.92 |
| CHEMBL3764264 | — | — | 1 | 6.88 |
| CHEMBL3763866 | — | — | 1 | 6.82 |
| CHEMBL3763178 | — | — | 1 | 6.73 |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 6.70 |
| CHEMBL3763917 | — | — | 1 | 6.69 |
| CHEMBL3763786 | — | — | 1 | 6.65 |
| CHEMBL3764587 | — | — | 1 | 6.58 |
| CHEMBL3764804 | — | — | 1 | 6.56 |
| CHEMBL3763614 | — | — | 1 | 6.55 |
| CHEMBL3765049 | — | — | 1 | 6.48 |
| CHEMBL3764806 | — | — | 1 | 6.46 |
| CHEMBL3765508 | — | — | 1 | 6.42 |
| CHEMBL3763276 | — | — | 1 | 6.33 |
| CHEMBL3763542 | — | — | 1 | 6.30 |
| CHEMBL3764627 | — | — | 1 | 6.24 |
| CHEMBL3764355 | — | — | 1 | 6.23 |
| CHEMBL3763356 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764984 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3765311 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3764454 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3765413 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3763554 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3763933 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3765513 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3763799 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3765459 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3764176 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3764511 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3764594 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3763385 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL3764264 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL3763866 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3763178 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 198.0 | nM | 6.70 |
| CHEMBL3763917 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3763786 | — | EC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3764587 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3764804 | — | EC50 | = | 275.0 | nM | 6.56 |
| CHEMBL3763614 | — | EC50 | = | 279.0 | nM | 6.55 |
| CHEMBL3765049 | — | EC50 | = | 329.0 | nM | 6.48 |
| CHEMBL3764806 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3765508 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3763276 | — | EC50 | = | 471.0 | nM | 6.33 |
| CHEMBL3763542 | — | EC50 | = | 497.0 | nM | 6.30 |
| CHEMBL3764627 | — | EC50 | = | 579.0 | nM | 6.24 |
| CHEMBL3764355 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3763356 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3765298 | — | EC50 | = | 728.0 | nM | 6.14 |
| CHEMBL3765506 | — | EC50 | = | 921.0 | nM | 6.04 |
| CHEMBL3765292 | — | EC50 | = | 1148.0 | nM | 5.94 |
| CHEMBL3765172 | — | EC50 | = | 1598.0 | nM | 5.80 |
| CHEMBL3763420 | — | EC50 | = | 2333.0 | nM | 5.63 |
| CHEMBL3764952 | — | EC50 | = | 9917.0 | nM | 5.00 |
| CHEMBL3765461 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL3765278 | — | EC50 | > | 1000.0 | nM | - |