Compound Detail
CHEMBL3765413
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COC(=O)N[C@H](C(=O)N1C[Si](C)(C)C[C@H]1c1nc2ccc3cc(-c4ccc(-c5cnc([C@@H]6C[C@H]7C[C@H]7N6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]5)cc4)ccc3c2[nH]1)C(C)C
Basic Information
| ChEMBL ID | CHEMBL3765413 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRBAPHMVOFZGEL-PYSSUHOPSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
819.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis C virus CHEMBL379 | EC50 | 7.52 | 7.52 | 30.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis C virus | EC50 | = | 30.0 | nM | 7.52 | Antiviral activity against HCV genotype 1a expressing NS5A Y93H mutant by replic... | 26850003 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26850003 | 10.1016/j.bmcl.2016.01.050 | Hepatitis C virus | 3 |
Data from ChEMBL 36 via Core Engine