Compound Detail
CHEMBL3763178
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COC(=O)N[C@H](C(=O)N1C[Si](C)(C)C[C@H]1c1ncc(-c2ccc(-c3ccc4c(ccc5nc([C@@H]6CCCN6C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]c54)c3)nc2)[nH]1)C(C)C
Basic Information
| ChEMBL ID | CHEMBL3763178 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HMOTUSYTEXDHHX-BBACVFHCSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
808.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 10.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatitis C virus CHEMBL379 | EC50 | 10.85 | 9.3267 | 0.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatitis C virus | EC50 | = | 0.014 | nM | 10.85 | Antiviral activity against HCV genotype 1b by replicon assay | 26850003 |
| Hepatitis C virus | EC50 | = | 0.04 | nM | 10.4 | Antiviral activity against HCV genotype 1a by replicon assay | 26850003 |
| Hepatitis C virus | EC50 | = | 185.0 | nM | 6.73 | Antiviral activity against HCV genotype 1a expressing NS5A Y93H mutant by replic... | 26850003 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26850003 | 10.1016/j.bmcl.2016.01.050 | Hepatitis C virus | 3 |
Data from ChEMBL 36 via Core Engine