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Assay Detail

CHEMBL3767400

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Functional
Antiviral activity against HCV genotype 1b by replicon assay
ChEMBL ↗
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development.
Nair AG, Zeng Q, Selyutin O, Rosenblum SB, Jiang Y, Yang DY, Keertikar K, Zhou G, Dwyer MP, Kim SH, Shankar B, Yu W, Tong L, Chen L, Mazzola R, Caldwell J, Tang H, Allard ML, Buckle RN, Gauuan PJ, Holst CL, Martin GS, Naicker KP, Vellekoop S, Agrawal S, Liu R, Kong R, Ingravallo P, Xia E, Zhai Y, Nomeir A, Kozlowski JA.
Bioorg Med Chem Lett (2016) 26 : 1475 -1479
PubMed 26850003 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 10.97 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3765278 — — 1 11.00
CHEMBL3765508 — — 1 11.00
CHEMBL3764264 — — 1 11.00
CHEMBL2023898 DACLATASVIR 4.0 1 11.00
CHEMBL3763178 — — 1 10.85
CHEMBL3763385 — — 1 -
CHEMBL3764511 — — 1 -
CHEMBL3764594 — — 1 -
CHEMBL3763554 — — 1 -
CHEMBL3764806 — — 1 -
CHEMBL3764952 — — 1 -
CHEMBL3763420 — — 1 -
CHEMBL3765506 — — 1 -
CHEMBL3765049 — — 1 -
CHEMBL3763542 — — 1 -
CHEMBL3765172 — — 1 -
CHEMBL3765292 — — 1 -
CHEMBL3763917 — — 1 -
CHEMBL3765298 — — 1 -
CHEMBL3765513 — — 1 -
CHEMBL3764454 — — 1 -
CHEMBL3763933 — — 1 -
CHEMBL3764176 — — 1 -
CHEMBL3765413 — — 1 -
CHEMBL3763799 — — 1 -
CHEMBL3764984 — — 1 -
CHEMBL3763866 — — 1 -
CHEMBL3765311 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3765278 — EC50 = 0.01 nM 11.00
CHEMBL3765508 — EC50 = 0.01 nM 11.00
CHEMBL3764264 — EC50 = 0.01 nM 11.00
CHEMBL2023898 DACLATASVIR EC50 = 0.01 nM 11.00
CHEMBL3763178 — EC50 = 0.014 nM 10.85
CHEMBL3763385 — EC50 = 0.004 nM -
CHEMBL3764511 — EC50 = 0.003 nM -
CHEMBL3764594 — EC50 = 0.003 nM -
CHEMBL3763554 — EC50 = 0.004 nM -
CHEMBL3764806 — EC50 = 0.005 nM -
CHEMBL3764952 — EC50 = 0.004 nM -
CHEMBL3763420 — EC50 = 0.006 nM -
CHEMBL3765506 — EC50 = 0.004 nM -
CHEMBL3765049 — EC50 = 0.004 nM -
CHEMBL3763542 — EC50 = 0.004 nM -
CHEMBL3765172 — EC50 = 0.007 nM -
CHEMBL3765292 — EC50 = 0.008 nM -
CHEMBL3763917 — EC50 = 0.002 nM -
CHEMBL3765298 — EC50 = 0.009 nM -
CHEMBL3765513 — EC50 = 0.003 nM -
CHEMBL3764454 — EC50 = 0.006 nM -
CHEMBL3763933 — EC50 = 0.005 nM -
CHEMBL3764176 — EC50 = 0.003 nM -
CHEMBL3765413 — EC50 = 0.002 nM -
CHEMBL3763799 — EC50 = 0.002 nM -
CHEMBL3764984 — EC50 = 0.003 nM -
CHEMBL3763866 — EC50 = 0.003 nM -
CHEMBL3765311 — EC50 = 0.001 nM -