Assay Detail
Functional
CHEMBL3767436
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Cytotoxicity against human THP1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Induction of apoptosis by cyclobutanones and derived polycyclic -lactones: a preliminary analysis of antiproliferative activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.13 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 8.00 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 7.70 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.30 |
| CHEMBL3764958 | — | — | 1 | 5.00 |
| CHEMBL3764164 | — | — | 1 | 5.00 |
| CHEMBL3763555 | — | — | 1 | 4.75 |
| CHEMBL3765091 | — | — | 1 | - |
| CHEMBL3763500 | — | — | 1 | - |
| CHEMBL3765652 | — | — | 1 | - |
| CHEMBL3765768 | — | — | 1 | - |
| CHEMBL3763291 | — | — | 1 | - |
| CHEMBL3765664 | — | — | 1 | - |
| CHEMBL3765519 | — | — | 1 | - |
| CHEMBL3765380 | — | — | 1 | - |
| CHEMBL3765109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3764958 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3764164 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3763555 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3765091 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3763500 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765652 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765768 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3763291 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765664 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765519 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765380 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765109 | — | IC50 | > | 50000.0 | nM | - |