Assay Detail
Functional
CHEMBL3767488
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Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 30 mins measured 1 hr post Ab-Cryptate and IP1-d2 addition by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.38 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763951 | — | — | 1 | 5.38 |
| CHEMBL3763342 | — | — | 1 | - |
| CHEMBL3764572 | — | — | 1 | - |
| CHEMBL3765525 | — | — | 1 | - |
| CHEMBL3763217 | — | — | 1 | - |
| CHEMBL3763823 | — | — | 1 | - |
| CHEMBL3763620 | — | — | 1 | - |
| CHEMBL3765356 | — | — | 1 | - |
| CHEMBL3763174 | — | — | 1 | - |
| CHEMBL3765689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763951 | — | IC50 | = | 4129.0 | nM | 5.38 |
| CHEMBL3763342 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3764572 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3765525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3763217 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3763823 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3763620 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3765356 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3763174 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3765689 | — | IC50 | > | 10000.0 | nM | - |