Assay Detail
Functional
CHEMBL3767557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KG1a cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1a |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.40 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.09 |
| CHEMBL3765076 | — | — | 1 | 5.12 |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3765076 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | IC50 | = | 10500.0 | nM | 4.98 |