Assay Detail
Binding
CHEMBL3767808
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Displacement of [3H]-DTG from sigma 2 receptor in Wistar hannover rat liver membrane after 120 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.46 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2437387 | — | — | 1 | 8.37 |
| CHEMBL176941 | — | — | 1 | 7.75 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.45 |
| CHEMBL3763740 | — | — | 1 | 7.42 |
| CHEMBL3763396 | — | — | 1 | 7.34 |
| CHEMBL3765740 | — | — | 1 | 7.32 |
| CHEMBL177952 | — | — | 1 | 7.31 |
| CHEMBL573234 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2437387 | — | Ki | = | 4.24 | nM | 8.37 |
| CHEMBL176941 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 35.4 | nM | 7.45 |
| CHEMBL3763740 | — | Ki | = | 38.4 | nM | 7.42 |
| CHEMBL3763396 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL3765740 | — | Ki | = | 48.3 | nM | 7.32 |
| CHEMBL177952 | — | Ki | = | 48.7 | nM | 7.31 |
| CHEMBL573234 | — | Ki | = | 179.0 | nM | 6.75 |