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Compound Detail

CHEMBL573234

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COc1cccc2c1CCCC2CCC(=O)N1CCN(C2CCCCC2)CC1

Basic Information

ChEMBL ID CHEMBL573234
Phase Preclinical
Structure Type MOL
InChI Key HFJOSVHIASIIRD-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

384.6
MW (Da)
4.37
ALogP
3
HBA
0
HBD
32.8
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H36N2O2
MW 384.56
Aromatic Rings 1
Heavy Atoms 28
NP-Likeness -0.62

Activity Summary

Ki 5 meas. best 9.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sigma non-opioid intracellular receptor 1
CHEMBL4153
Ki 9.96 9.96 0.1 2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL5525
Ki 8.13 8.13 7.4 1
Unchecked
CHEMBL612545
Ki 6.75 6.75 179.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19842660 10.1021/jm9007505 Unchecked 2
19842660 10.1021/jm9007505 Sigma non-opioid intracellular receptor 1 1
19842660 10.1021/jm9007505 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
26717207 10.1016/j.ejmech.2015.12.014 Sigma non-opioid intracellular receptor 1 1
26717207 10.1016/j.ejmech.2015.12.014 Unchecked 1

Data from ChEMBL 36 via Core Engine