Assay Detail
Binding
CHEMBL1059305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+/-)-emopamil from EBP in Dunkin guinea pig liver membrane by radioreceptor binding assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL5525) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.49 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573932 | — | — | 1 | 8.84 |
| CHEMBL574821 | — | — | 1 | 8.33 |
| CHEMBL583580 | — | — | 1 | 8.13 |
| CHEMBL573234 | — | — | 1 | 8.13 |
| CHEMBL53325 | — | — | 1 | 8.08 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 7.99 |
| CHEMBL573695 | — | — | 1 | 7.98 |
| CHEMBL134607 | — | — | 1 | 7.96 |
| CHEMBL573703 | — | — | 1 | 7.77 |
| CHEMBL574598 | — | — | 1 | 7.64 |
| CHEMBL582875 | — | — | 1 | 7.50 |
| CHEMBL50079 | — | — | 1 | 7.45 |
| CHEMBL584767 | — | — | 1 | 7.31 |
| CHEMBL575238 | — | — | 1 | 7.19 |
| CHEMBL573248 | — | — | 1 | 6.82 |
| CHEMBL573704 | — | — | 1 | 6.64 |
| CHEMBL575253 | — | — | 1 | 6.33 |
| CHEMBL573461 | — | — | 1 | 6.26 |
| CHEMBL575262 | — | — | 1 | 5.91 |
| CHEMBL574182 | — | — | 1 | - |
| CHEMBL574165 | — | — | 1 | - |
| CHEMBL575239 | — | — | 1 | - |
| CHEMBL576193 | — | — | 1 | - |
| CHEMBL583945 | — | — | 1 | - |
| CHEMBL574155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573932 | — | Ki | = | 1.46 | nM | 8.84 |
| CHEMBL574821 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL583580 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL573234 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL53325 | — | Ki | = | 8.38 | nM | 8.08 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL573695 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL134607 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL573703 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL574598 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL582875 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL50079 | — | Ki | = | 35.4 | nM | 7.45 |
| CHEMBL584767 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL575238 | — | Ki | = | 64.4 | nM | 7.19 |
| CHEMBL573248 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL573704 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL575253 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL573461 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL575262 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL574182 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL574165 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL575239 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL576193 | — | Ki | - | — | - | |
| CHEMBL583945 | — | Ki | - | — | - | |
| CHEMBL574155 | — | Ki | - | — | - |