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Compound Detail

CHEMBL575262

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COc1cccc2c1CCCC2CCCNCC(=O)NC1CCCCC1

Basic Information

ChEMBL ID CHEMBL575262
Phase Preclinical
Structure Type MOL
InChI Key FPZFBYULDIDYBF-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

358.5
MW (Da)
3.93
ALogP
3
HBA
2
HBD
50.4
PSA (Ų)
0.69
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H34N2O2
MW 358.53
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness -0.43

Activity Summary

Ki 3 meas. best 6.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 6.1 6.1 798.0 1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL5525
Ki 5.91 5.91 1230.0 1
Sigma non-opioid intracellular receptor 1
CHEMBL4153
Ki 5.41 5.41 3910.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19842660 10.1021/jm9007505 Unchecked 2
19842660 10.1021/jm9007505 Sigma non-opioid intracellular receptor 1 1
19842660 10.1021/jm9007505 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1

Data from ChEMBL 36 via Core Engine