Assay Detail
Binding
CHEMBL3767807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-pentazocine from sigma 1 receptor in guinea pig brain membrane after 120 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.51 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176941 | — | — | 1 | 10.52 |
| CHEMBL573234 | — | — | 1 | 9.96 |
| CHEMBL177952 | — | — | 1 | 9.00 |
| CHEMBL3765740 | — | — | 1 | 8.44 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 8.35 |
| CHEMBL3763396 | — | — | 1 | 8.28 |
| CHEMBL3763740 | — | — | 1 | 7.88 |
| CHEMBL2437387 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176941 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL573234 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL177952 | — | Ki | = | 1.01 | nM | 9.00 |
| CHEMBL3765740 | — | Ki | = | 3.61 | nM | 8.44 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 4.52 | nM | 8.35 |
| CHEMBL3763396 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL3763740 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL2437387 | — | Ki | = | 2435.0 | nM | 5.61 |