Assay Detail
Binding
CHEMBL3767955
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Inhibition of ABCG2 in human MCF7/Topo cells by Hoechst 33342 assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7/Topo |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.83 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 6.28 |
| CHEMBL410316 | FUMITREMORGIN | — | 1 | 6.14 |
| CHEMBL2011282 | — | — | 1 | 5.75 |
| CHEMBL3763735 | — | — | 1 | 4.92 |
| CHEMBL3763441 | — | — | 1 | 4.91 |
| CHEMBL2011285 | — | — | 1 | 4.79 |
| CHEMBL3763734 | — | — | 1 | 4.46 |
| CHEMBL3765024 | — | — | 1 | 4.43 |
| CHEMBL3764197 | — | — | 1 | 4.42 |
| CHEMBL3765551 | — | — | 1 | 4.42 |
| CHEMBL3764781 | — | — | 1 | 4.18 |
| CHEMBL3764296 | — | — | 1 | 4.06 |
| CHEMBL3763752 | — | — | 1 | 4.00 |
| CHEMBL3764821 | — | — | 1 | - |
| CHEMBL3763435 | — | — | 1 | - |
| CHEMBL3764329 | — | — | 1 | - |
| CHEMBL3763290 | — | — | 1 | - |
| CHEMBL3763285 | — | — | 1 | - |
| CHEMBL3765286 | — | — | 1 | - |
| CHEMBL3764262 | — | — | 1 | - |
| CHEMBL1506885 | — | — | 1 | - |
| CHEMBL89768 | — | — | 1 | - |
| CHEMBL3764960 | — | — | 1 | - |
| CHEMBL3763433 | — | — | 1 | - |
| CHEMBL3763302 | — | — | 1 | - |
| CHEMBL3765802 | — | — | 1 | - |
| CHEMBL3763583 | — | — | 1 | - |
| CHEMBL3764042 | — | — | 1 | - |
| CHEMBL3764599 | — | — | 1 | - |
| CHEMBL3765272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL410316 | FUMITREMORGIN | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL2011282 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3763735 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3763441 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL2011285 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL3763734 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL3765024 | — | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL3764197 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL3765551 | — | IC50 | = | 37600.0 | nM | 4.42 |
| CHEMBL3764781 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL3764296 | — | IC50 | = | 87800.0 | nM | 4.06 |
| CHEMBL3763752 | — | IC50 | = | 99700.0 | nM | 4.00 |
| CHEMBL3763817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3765052 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764821 | — | IC50 | - | — | - | |
| CHEMBL3763435 | — | IC50 | - | — | - | |
| CHEMBL3764329 | — | IC50 | - | — | - | |
| CHEMBL3763290 | — | IC50 | - | — | - | |
| CHEMBL3763285 | — | IC50 | - | — | - | |
| CHEMBL3765286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764262 | — | IC50 | - | — | - | |
| CHEMBL1506885 | — | IC50 | - | — | - | |
| CHEMBL89768 | — | IC50 | - | — | - | |
| CHEMBL3764960 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763433 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763302 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3765802 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763583 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764042 | — | IC50 | - | — | - | |
| CHEMBL3764599 | — | IC50 | - | — | - | |
| CHEMBL3765272 | — | IC50 | - | — | - |