Assay Detail
Binding
CHEMBL3767965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-methyltrienolone from androgen receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.66 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166444 | METRIBOLONE | 2.0 | 1 | 9.40 |
| CHEMBL3765171 | — | — | 1 | 9.17 |
| CHEMBL3764185 | — | — | 1 | 8.69 |
| CHEMBL3764446 | — | — | 1 | 8.28 |
| CHEMBL3765823 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166444 | METRIBOLONE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL3765171 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL3764185 | — | Ki | = | 2.03 | nM | 8.69 |
| CHEMBL3764446 | — | Ki | = | 5.21 | nM | 8.28 |
| CHEMBL3765823 | — | Ki | = | 16.9 | nM | 7.77 |