Assay Detail
Binding
CHEMBL3767969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human androgen receptor expressed in mouse C2C12 cells cotransfected with GRE/ARE reporter plasmid assessed as receptor transactivation after 48 hrs by luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C2C12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.21 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166444 | METRIBOLONE | 2.0 | 1 | 10.89 |
| CHEMBL3765171 | — | — | 1 | 10.40 |
| CHEMBL3764185 | — | — | 1 | 9.30 |
| CHEMBL3765823 | — | — | 1 | 8.31 |
| CHEMBL3764446 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166444 | METRIBOLONE | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL3765171 | — | EC50 | = | 0.0398 | nM | 10.40 |
| CHEMBL3764185 | — | EC50 | = | 0.499 | nM | 9.30 |
| CHEMBL3765823 | — | EC50 | = | 4.88 | nM | 8.31 |
| CHEMBL3764446 | — | EC50 | = | 73.7 | nM | 7.13 |