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Assay Detail

CHEMBL3768088

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of human WM115 cells expressing low levels of S100-B by SYBR Green based fluorescence method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type WM-115
Confidence 1 — Organism
Curated By Autocuration

Publication

Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Cavalier MC, Ansari MI, Pierce AD, Wilder PT, McKnight LE, Raman EP, Neau DB, Bezawada P, Alasady MJ, Charpentier TH, Varney KM, Toth EA, MacKerell AD, Coop A, Weber DJ.
J Med Chem (2016) 59 : 592 -608
PubMed 26727270 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 4.72 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3763393 1 6.30
CHEMBL3764250 1 5.32
CHEMBL3764125 1 5.04
CHEMBL55 PENTAMIDINE 4.0 1 4.78
CHEMBL3763804 1 4.72
CHEMBL3765771 1 4.67
CHEMBL3763465 1 4.61
CHEMBL2206238 HEPTAMIDINE 1 4.59
CHEMBL3764851 1 4.59
CHEMBL3765382 1 4.48
CHEMBL3765734 1 4.46
CHEMBL3765503 1 4.42
CHEMBL22831 1 4.41
CHEMBL3764696 1 4.39
CHEMBL3765671 1 4.37
CHEMBL3764285 1 4.34
CHEMBL3764132 1 -
CHEMBL3765514 1 -
CHEMBL3764116 1 -
CHEMBL3765054 1 -
CHEMBL3245411 1 -
CHEMBL3764529 1 -
CHEMBL289577 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3763393 EC50 = 500.0 nM 6.30
CHEMBL3764250 EC50 = 4800.0 nM 5.32
CHEMBL3764125 EC50 = 9200.0 nM 5.04
CHEMBL55 PENTAMIDINE EC50 = 16700.0 nM 4.78
CHEMBL3763804 EC50 = 19000.0 nM 4.72
CHEMBL3765771 EC50 = 21200.0 nM 4.67
CHEMBL3763465 EC50 = 24300.0 nM 4.61
CHEMBL2206238 HEPTAMIDINE EC50 = 25600.0 nM 4.59
CHEMBL3764851 EC50 = 25400.0 nM 4.59
CHEMBL3765382 EC50 = 33300.0 nM 4.48
CHEMBL3765734 EC50 = 34500.0 nM 4.46
CHEMBL3765503 EC50 = 37900.0 nM 4.42
CHEMBL22831 EC50 = 38900.0 nM 4.41
CHEMBL3764696 EC50 = 41000.0 nM 4.39
CHEMBL3765671 EC50 = 42700.0 nM 4.37
CHEMBL3764285 EC50 = 45800.0 nM 4.34
CHEMBL3764132 EC50 = 301200.0 nM -
CHEMBL3765514 EC50 = 283600.0 nM -
CHEMBL3764116 EC50 = 288900.0 nM -
CHEMBL3765054 EC50 = 146100.0 nM -
CHEMBL3245411 EC50 = 234000.0 nM -
CHEMBL3764529 EC50 = 500100.0 nM -
CHEMBL289577 EC50 < 1000.0 nM -