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Assay Detail

CHEMBL3768247

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
ChEMBL ↗
58
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 7 (CHEMBL3155) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.
Kim Y, Yeom M, Tae J, Rhim H, Choo H.
Eur J Med Chem (2016) 110 : 302 -310
PubMed 26852005 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 58 6.46 9.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL282199 — — 2 9.47
CHEMBL3763779 — — 2 7.52
CHEMBL3764335 — — 2 7.42
CHEMBL3764650 — — 2 7.13
CHEMBL3764133 — — 2 7.07
CHEMBL3763677 — — 2 6.90
CHEMBL3763582 — — 2 6.82
CHEMBL3765511 — — 2 6.80
CHEMBL3763329 — — 2 6.60
CHEMBL3764418 — — 2 6.55
CHEMBL3763275 — — 2 6.51
CHEMBL3764178 — — 2 6.44
CHEMBL3763883 — — 2 6.29
CHEMBL3764136 — — 2 6.26
CHEMBL3764661 — — 2 6.23
CHEMBL3765794 — — 2 6.22
CHEMBL3764364 — — 2 6.21
CHEMBL3765223 — — 2 6.17
CHEMBL3764970 — — 2 6.10
CHEMBL3763858 — — 2 6.08
CHEMBL3764477 — — 2 6.02
CHEMBL3763534 — — 2 5.98
CHEMBL3763504 — — 2 5.97
CHEMBL3765208 — — 2 5.89
CHEMBL3763567 — — 2 5.88
CHEMBL3764307 — — 2 5.85
CHEMBL3764934 — — 2 5.72
CHEMBL3763670 — — 2 5.67
CHEMBL3764889 — — 2 5.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL282199 — Ki = 0.34 nM 9.47
CHEMBL282199 — Ki = 0.3388 nM 9.47
CHEMBL3763779 — Ki = 30.0 nM 7.52
CHEMBL3763779 — Ki = 30.2 nM 7.52
CHEMBL3764335 — Ki = 38.0 nM 7.42
CHEMBL3764335 — Ki = 38.02 nM 7.42
CHEMBL3764650 — Ki = 74.0 nM 7.13
CHEMBL3764650 — Ki = 74.13 nM 7.13
CHEMBL3764133 — Ki = 86.0 nM 7.07
CHEMBL3764133 — Ki = 87.1 nM 7.06
CHEMBL3763677 — Ki = 125.89 nM 6.90
CHEMBL3763677 — Ki = 127.0 nM 6.90
CHEMBL3763582 — Ki = 153.0 nM 6.82
CHEMBL3763582 — Ki = 151.36 nM 6.82
CHEMBL3765511 — Ki = 158.49 nM 6.80
CHEMBL3765511 — Ki = 157.0 nM 6.80
CHEMBL3763329 — Ki = 252.0 nM 6.60
CHEMBL3763329 — Ki = 251.19 nM 6.60
CHEMBL3764418 — Ki = 282.0 nM 6.55
CHEMBL3764418 — Ki = 281.84 nM 6.55
CHEMBL3763275 — Ki = 312.0 nM 6.51
CHEMBL3763275 — Ki = 309.03 nM 6.51
CHEMBL3764178 — Ki = 364.0 nM 6.44
CHEMBL3764178 — Ki = 363.08 nM 6.44
CHEMBL3763883 — Ki = 513.0 nM 6.29
CHEMBL3763883 — Ki = 512.86 nM 6.29
CHEMBL3764136 — Ki = 550.0 nM 6.26
CHEMBL3764136 — Ki = 549.54 nM 6.26
CHEMBL3764661 — Ki = 592.0 nM 6.23
CHEMBL3764661 — Ki = 588.84 nM 6.23
CHEMBL3765794 — Ki = 602.56 nM 6.22
CHEMBL3765794 — Ki = 604.0 nM 6.22
CHEMBL3764364 — Ki = 616.0 nM 6.21
CHEMBL3764364 — Ki = 616.6 nM 6.21
CHEMBL3765223 — Ki = 676.08 nM 6.17
CHEMBL3765223 — Ki = 680.0 nM 6.17
CHEMBL3764970 — Ki = 794.33 nM 6.10
CHEMBL3763858 — Ki = 831.76 nM 6.08
CHEMBL3763858 — Ki = 833.0 nM 6.08
CHEMBL3764970 — Ki = 883.0 nM 6.05
CHEMBL3764477 — Ki = 949.0 nM 6.02
CHEMBL3764477 — Ki = 954.99 nM 6.02
CHEMBL3763534 — Ki = 1051.0 nM 5.98
CHEMBL3763534 — Ki = 1047.13 nM 5.98
CHEMBL3763504 — Ki = 1072.0 nM 5.97
CHEMBL3763504 — Ki = 1071.52 nM 5.97
CHEMBL3765208 — Ki = 1281.0 nM 5.89
CHEMBL3765208 — Ki = 1288.25 nM 5.89
CHEMBL3763567 — Ki = 1307.0 nM 5.88
CHEMBL3763567 — Ki = 1318.26 nM 5.88