Assay Detail
Functional
CHEMBL3768346
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Cytotoxicity against human MKN45 cells after 72 hrs by MTT assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.33 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 7.64 |
| CHEMBL3764279 | — | — | 1 | 7.41 |
| CHEMBL3764523 | — | — | 1 | 7.22 |
| CHEMBL3763970 | — | — | 1 | 6.85 |
| CHEMBL3765283 | — | — | 1 | 6.75 |
| CHEMBL3764610 | — | — | 1 | 6.57 |
| CHEMBL3764782 | — | — | 1 | 6.50 |
| CHEMBL3764780 | — | — | 1 | 6.46 |
| CHEMBL3765709 | — | — | 1 | 6.38 |
| CHEMBL3763852 | — | — | 1 | 6.34 |
| CHEMBL3763544 | — | — | 1 | 6.33 |
| CHEMBL3765572 | — | — | 1 | 6.33 |
| CHEMBL3763835 | — | — | 1 | 6.30 |
| CHEMBL3763886 | — | — | 1 | 6.28 |
| CHEMBL3765825 | — | — | 1 | 6.20 |
| CHEMBL3765241 | — | — | 1 | 6.20 |
| CHEMBL3764241 | — | — | 1 | 6.18 |
| CHEMBL3764971 | — | — | 1 | 6.17 |
| CHEMBL3764158 | — | — | 1 | 6.15 |
| CHEMBL3765124 | — | — | 1 | 6.13 |
| CHEMBL3764198 | — | — | 1 | 6.13 |
| CHEMBL3764320 | — | — | 1 | 6.12 |
| CHEMBL3765600 | — | — | 1 | 6.12 |
| CHEMBL3764184 | — | — | 1 | 6.11 |
| CHEMBL3764060 | — | — | 1 | 6.09 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 6.09 |
| CHEMBL3764722 | — | — | 1 | 6.08 |
| CHEMBL3765043 | — | — | 1 | 6.07 |
| CHEMBL3763874 | — | — | 1 | 6.06 |
| CHEMBL3763783 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3764279 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3764523 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3763970 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3765283 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3764610 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3764782 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3764780 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3765709 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3763852 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3763544 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3765572 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3763835 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3763886 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3765241 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3765825 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3764241 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3764971 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3764158 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3765124 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3764198 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3764320 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3765600 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3764184 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3764060 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL591429 | PAC-1 | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3764722 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3765043 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3763874 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3763783 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3763986 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3764550 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3764494 | — | IC50 | = | 1990.0 | nM | 5.70 |