Assay Detail
Functional
CHEMBL3768903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate incubated for 5 mins by spectrophotometric analysis
29
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory neolignans from the roots of Magnolia officinalis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.41 | 6.20 |
| Inhibition | 14 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765299 | — | — | 2 | 6.20 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.70 |
| CHEMBL3763606 | — | — | 2 | 5.67 |
| CHEMBL3765630 | — | — | 2 | 5.65 |
| CHEMBL3764918 | — | — | 2 | 5.59 |
| CHEMBL491809 | OBOVATOR | — | 2 | 5.48 |
| CHEMBL3763258 | — | — | 2 | 5.47 |
| CHEMBL3764643 | — | — | 2 | 5.45 |
| CHEMBL3765073 | — | — | 2 | 5.43 |
| CHEMBL3764367 | — | — | 2 | 5.42 |
| CHEMBL89700 | METHYLHONOKIOL | — | 2 | 5.09 |
| CHEMBL3763856 | — | — | 2 | 4.97 |
| CHEMBL3765325 | — | — | 2 | 4.83 |
| CHEMBL3765482 | — | — | 2 | 4.74 |
| CHEMBL3763185 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765299 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3763606 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL3765630 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL3764918 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL491809 | OBOVATOR | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3763258 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL3764643 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL3765073 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3764367 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL89700 | METHYLHONOKIOL | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL3763856 | — | IC50 | = | 10690.0 | nM | 4.97 |
| CHEMBL3765325 | — | IC50 | = | 14850.0 | nM | 4.83 |
| CHEMBL3765482 | — | IC50 | = | 18250.0 | nM | 4.74 |
| CHEMBL3763185 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3765299 | — | Inhibition | - | % | - | |
| CHEMBL3764643 | — | Inhibition | - | % | - | |
| CHEMBL3763606 | — | Inhibition | - | % | - | |
| CHEMBL3763856 | — | Inhibition | - | % | - | |
| CHEMBL3764918 | — | Inhibition | - | % | - | |
| CHEMBL3765073 | — | Inhibition | - | % | - | |
| CHEMBL3765630 | — | Inhibition | - | % | - | |
| CHEMBL3764367 | — | Inhibition | - | % | - | |
| CHEMBL3765482 | — | Inhibition | - | % | - | |
| CHEMBL3765325 | — | Inhibition | - | % | - | |
| CHEMBL89700 | METHYLHONOKIOL | Inhibition | - | % | - | |
| CHEMBL491809 | OBOVATOR | Inhibition | - | % | - | |
| CHEMBL3763258 | — | Inhibition | - | % | - | |
| CHEMBL3763185 | — | Inhibition | - | % | - |