Assay Detail
Functional
CHEMBL3769003
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Antiproliferative activity against human CEM cells assessed as cell survival after 72 hrs by coulter counter analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.62 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764662 | — | — | 1 | 6.42 |
| CHEMBL3764683 | — | — | 1 | 6.41 |
| CHEMBL3763807 | — | — | 1 | 6.28 |
| CHEMBL3763325 | — | — | 1 | 6.19 |
| CHEMBL3763402 | — | — | 1 | 5.94 |
| CHEMBL3764362 | — | — | 1 | 5.78 |
| CHEMBL154716 | — | — | 1 | 5.77 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.61 |
| CHEMBL129134 | — | — | 1 | 5.47 |
| CHEMBL2391734 | — | — | 1 | 5.40 |
| CHEMBL482409 | — | — | 1 | 5.16 |
| CHEMBL2391731 | — | — | 1 | 5.15 |
| CHEMBL2036329 | — | — | 1 | 4.88 |
| CHEMBL3764404 | — | — | 1 | 4.21 |
| CHEMBL3765303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764662 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL3764683 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3763807 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3763325 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3763402 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL3764362 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL154716 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL129134 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL2391734 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL482409 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL2391731 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL2036329 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3764404 | — | IC50 | = | 62100.0 | nM | 4.21 |
| CHEMBL3765303 | — | IC50 | > | 500000.0 | nM | - |