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Assay Detail

CHEMBL3769127

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human N-terminal truncated ChoKalpha1 (75 to 457 residues) by surface plasmon resonance assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Choline kinase alpha (CHEMBL3117)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
Zech SG, Kohlmann A, Zhou T, Li F, Squillace RM, Parillon LE, Greenfield MT, Miller DP, Qi J, Thomas RM, Wang Y, Xu Y, Miret JJ, Shakespeare WC, Zhu X, Dalgarno DC.
J Med Chem (2016) 59 : 671 -686
PubMed 26700752 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 20 5.72 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3763540 1 8.00
CHEMBL3764278 1 7.68
CHEMBL3763792 1 7.06
CHEMBL3763931 1 7.00
CHEMBL3765239 1 6.71
CHEMBL3763982 1 6.68
CHEMBL3763453 1 6.59
CHEMBL3763801 1 6.42
CHEMBL3764898 1 6.11
CHEMBL3764904 1 5.62
CHEMBL3763340 1 5.43
CHEMBL3764767 1 5.42
CHEMBL3765567 1 5.40
CHEMBL3765077 1 5.40
CHEMBL3765650 1 5.37
CHEMBL3764395 1 5.16
CHEMBL3763993 1 3.88
CHEMBL3765610 1 3.71
CHEMBL3763196 1 3.47
CHEMBL3764475 1 3.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3763540 Kd = 10.0 nM 8.00
CHEMBL3764278 Kd = 21.0 nM 7.68
CHEMBL3763792 Kd = 88.0 nM 7.06
CHEMBL3763931 Kd = 99.0 nM 7.00
CHEMBL3765239 Kd = 195.0 nM 6.71
CHEMBL3763982 Kd = 211.0 nM 6.68
CHEMBL3763453 Kd = 259.0 nM 6.59
CHEMBL3763801 Kd = 382.0 nM 6.42
CHEMBL3764898 Kd = 769.0 nM 6.11
CHEMBL3764904 Kd = 2400.0 nM 5.62
CHEMBL3763340 Kd = 3700.0 nM 5.43
CHEMBL3764767 Kd = 3800.0 nM 5.42
CHEMBL3765567 Kd = 4000.0 nM 5.40
CHEMBL3765077 Kd = 4000.0 nM 5.40
CHEMBL3765650 Kd = 4300.0 nM 5.37
CHEMBL3764395 Kd = 7000.0 nM 5.16
CHEMBL3763993 Kd = 132000.0 nM 3.88
CHEMBL3765610 Kd = 194000.0 nM 3.71
CHEMBL3763196 Kd = 340000.0 nM 3.47
CHEMBL3764475 Kd = 630000.0 nM 3.20